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1 Introduction Acute respiratory distress syndrome (ARDS) is a severe, life-threatening inflammatory condition of the lungs commonly triggered by infections such as bacterial pneumonia, viral pathogens (e.g., influenza and SARS-CoV-2), and systemic sepsis ( The pathogenesis of ARDS involves an exaggerated immune response that damages alveolar structures, disrupts the alveolar-capillary barrier, and promotes excessive inflammation, vascular leakage, and oxygenation failure ( Regulated cell death pathways, such as apoptosis, pyroptosis, necroptosis, and ferroptosis, play pivotal roles in controlling inflammation and maintaining tissue integrity

Topical glutathione is generally well tolerated

In this study, we tested the hypothesis that FOXO4-DRI treatment can selectively remove senescent cells in expanded human chondrocytes, thus enhancing their potential to generate high-quality cartilage

doi: 10.3389/fcvm.2022.922441 144 WinkelPHildenJHansenJFKastrupJKolmosHJKjllerEet al